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X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft.

Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements particularly helices also lead to improved specificity in renins for angiotensinogen substrates. RCSB PDB is funded by the National Science Foundation DBI , the US Department of Energy DE-SC , and the National Cancer Institute , National Institute of Allergy and Infectious Diseases , and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM Warning You are using a web browser that we do not support.

Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox. Contact us. Toggle navigation RCSB PDB. Validate Data Validation Server Validation API Information for Journals Validation Task Forces.

Deposit Data wwPDB OneDep System PDB-Dev. Navigation Tabs Structure Summary 3D View Annotations Experiment Sequence Genome Versions. Asymmetric Unit. Macromolecule Content Total Structure Weight: Display Files FASTA Sequence mmCIF Format mmCIF Format Header PDB Format PDB Format Header. This is version 1. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins. Dhanaraj, V. Hide Full Abstract. Reference Sequence. View more in-depth experimental data.

Revision History Full details and data files Version 1. Help Contact Us Documentation Website FAQ Glossary Service Status. RCSB PDB citation is hosted by. RCSB PDB is a member of the. RCSB Partners Nucleic Acid Database wwPDB Partners RCSB PDB PDBe PDBj BMRB EMDB.

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